Increased Severe Cases and New-Onset Type 1 Diabetes Among Children Presenting With Diabetic Ketoacidosis During First Year of COVID-19 Pandemic in Turkey

被引：6

作者：

Kiral, Eylem ^{[1
]}

Kirel, Birgul ^{[2
]}

Havan, Merve ^{[3
]}

Keskin, Mehmet ^{[4
]}

Karaoglan, Murat ^{[4
]}

Yildirim, Ahmet ^{[4
]}

Kangin, Murat ^{[5
]}

Talay, Mehmet Nur ^{[5
]}

Urun, Tuba ^{[5
]}

Altug, Umit ^{[6
]}

Kesici, Selman ^{[7
]}

Tufan, Erennur ^{[7
]}

Kacmaz, Ebru ^{[1
]}

Bozan, Gurkan ^{[1
]}

Azapagasi, Ebru ^{[8
]}

Uysal Yazici, Mutlu ^{[8
]}

Ozturk, Zeynelabidin ^{[8
]}

Yesilbas, Osman ^{[9
]}

Karaguzel, Gulay ^{[10
]}

Kaya, Gulay ^{[10
]}

Barlas, Ulkem ^{[11
]}

Duyu, Muhterem ^{[12
]}

Boyraz, Merve ^{[12
]}

Sevketoglu, Esra ^{[13
]}

Akcay, Nihal ^{[13
]}

Hancili, Suna ^{[14
]}

Guven, Ayla ^{[14
]}

Dursun, Oguz ^{[15
]}

Tekerek, Nazan Ulgen ^{[15
]}

Ozcifci, Gokcen ^{[16
]}

Yazici, Pinar ^{[17
]}

Turanli, Eda ^{[17
]}

Kendirli, Tanil ^{[18
]}

Kahveci, Fevzi ^{[18
]}

Yetimakman, Ayse Filiz ^{[19
]}

Citak, Agop ^{[20
]}

Sik, Guntulu ^{[20
]}

Bingol, Ibrahim ^{[20
]}

Aygun, Fatih ^{[21
]}

Durak, Cansu ^{[22
]}

Yilmaz, Resul ^{[22
]}

Bugrul, Fuat ^{[23
]}

Sari, Yusuf ^{[24
]}

Tekguc, Hakan ^{[25
]}

Albayrak, Hatice ^{[26
]}

Yener, Nazik ^{[26
]}

Agin, Hasan ^{[27
]}

Soydan, Ekin ^{[27
]}

Yildizdas, Dincer ^{[28
]}

Dilek, Semine Ozdemir ^{[29
]}

机构：

[1] Eskisehir Osmangazi Univ, Pediat Intens Care Unit, Fac Med, Eskisehir, Turkey

[2] Eskisehir Osmangazi Univ, Dept Pediat Endocrinol, Fac Med, Eskisehir, Turkey

[3] Univ Hlth Sci, Mersin City Hosp, Pediat Intens Care Unit, Mersin, Turkey

[4] Gaziantep Univ, Dept Pediat Endocrinol, Fac Med, Gaziantep, Turkey

[5] Univ Heath Sci, Gazi Yasargil Training & Res Hosp, Pediat Intens Care Unit, Diyarbakir, Turkey

[6] Univ Heath Sci, Sanliurfa Training & Res Hosp, Pediat Intens Care Unit, Sanliurfa, Turkey

[7] Hacettepe Univ, Pediat Intens Care Unit, Fac Med, Ankara, Turkey

[8] Dr Sami Ulus Gynecol Obstet & Child Hlth & Dis Tra, Pediat Intens Care Unit, Ankara, Turkey

[9] Karadeniz Tech Univ, Fac Med, Pediat Intens Care Unit, Trabzon, Turkey

[10] Karadeniz Tech Univ, Fac Med, Dept Pediat Endocrinol, Trabzon, Turkey

[11] Univ Hlth Sci, Bagcilar Training & Res Hosp, Pediat Intens Care Unit, Istanbul, Turkey

[12] Medeniyet Univ, Prof Dr Suleyman Yalcin City Hosp, Pediat Intens Care Unit, Istanbul, Turkey

[13] Univ Heath Sci, Bakirkoy Dr Sadi Konuk Res & Training Hosp, Pediat Intens Care Unit, Istanbul, Turkey

[14] Univ Heath Sci, Zeynep Kamil Women & Children Dis Traning & Res Ho, Dept Pediat Endocrinol, Istanbul, Turkey

[15] Akdeniz Univ, Pediat Intens Care Unit, Fac Med, Antalya, Turkey

[16] Univ Heath Sci, Van Training & Res Hosp, Van, Turkey

[17] Ege Univ, Pediat Intens Care Unit, Fac Med, Izmir, Turkey

[18] Ankara Univ, Pediat Intens Care Unit, Fac Med, Ankara, Turkey

[19] Kocaeli Univ, Pediat Intens Care Unit, Fac Med, Kocaeli, Turkey

[20] Acibadem Mehmet Ali Aydinlar Univ, Fac Med, Pediat Intens Care Unit, Istanbul, Turkey

[21] Istanbul Univ, Pediat Intens Care Unit, Cerrahpasa Med Fac, Istanbul, Turkey

[22] Selcuk Univ, Pediat Intens Care Unit, Fac Med, Konya, Turkey

[23] Selcuk Univ, Dept Pediat Endocrinol, Fac Med, Konya, Turkey

[24] Firat Univ, Pediat Intens Care Unit, Fac Med, Elazig, Turkey

[25] Dr Burhan Nalbantoglu Hosp, Pediat Intens Care Unit, Nicosia, Cyprus

[26] Ondokuz Mayis Univ, Pediat Intens Care Unit, Fac Med, Samsun, Turkey

[27] Dr Behcet Uz Childrens Hosp, Pediat Intens Care Unit, Izmir, Turkey

[28] Cukurova Univ, Pediat Intens Care Unit, Fac Med, Adana, Turkey

[29] Cukurova Univ, Dept Pediat Endocrinol, Fac Med, Adana, Turkey

[30] Marmara Univ, Pediat Intens Care Unit, Fac Med, Istanbul, Turkey

[31] Trakya Univ, Pediat Intens Care Unit, Fac Med, Edirne, Turkey

[32] Trakya Univ, Dept Pediat Endocrinol, Fac Med, Edirne, Turkey

[33] Eskisehir Osmangazi Univ, Dept Biostat, Fac Med, Eskisehir, Turkey

来源：

FRONTIERS IN PEDIATRICS | 2022年 / 10卷

关键词：

COVID-19; children; diabetes; diabetic ketoacidosis; pandemic; pediatric intensive care unit; RISK;

D O I：

10.3389/fped.2022.926013

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

IntroductionThere have been some significant changes regarding healthcare utilization during the COVID-19 pandemic. Majority of the reports about the impact of the COVID-19 pandemic on diabetes care are from the first wave of the pandemic. We aim to evaluate the potential effects of the COVID-19 pandemic on the severity of diabetic ketoacidosis (DKA) and new onset Type 1 diabetes presenting with DKA, and also evaluate children with DKA and acute COVID-19 infection. MethodsThis is a retrospective multi-center study among 997 children and adolescents with type 1 diabetes who were admitted with DKA to 27 pediatric intensive care units in Turkey between the first year of pandemic and pre-pandemic year. ResultsThe percentage of children with new-onset Type 1 diabetes presenting with DKA was higher during the COVID-19 pandemic (p < 0.0001). The incidence of severe DKA was also higher during the COVID-19 pandemic (p < 0.0001) and also higher among children with new onset Type 1 diabetes (p < 0.0001). HbA1c levels, duration of insulin infusion, and length of PICU stay were significantly higher/longer during the pandemic period. Eleven patients tested positive for SARS-CoV-2, eight were positive for new onset Type 1 diabetes, and nine tested positive for severe DKA at admission. DiscussionThe frequency of new onset of Type 1 diabetes and severe cases among children with DKA during the first year of the COVID-19 pandemic. Furthermore, the cause of the increased severe presentation might be related to restrictions related to the pandemic; however, need to evaluate the potential effects of SARS-CoV-2 on the increased percentage of new onset Type 1 diabetes.

引用

页数：9

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