Sc(OTf)3-Mediated One-Pot Synthesis of 2,3-Disubstituted Quinolines from Anilines and Epoxides

被引：15

作者：

Al Mehedi, Md Shafaat ^{[1
]}

Tepe, Jetze J. ^{[1
]}

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48823 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 10期

基金：

美国国家卫生研究院;

关键词：

3-COMPONENT SYNTHESIS; FUNCTIONALIZATION; QUINAZOLINE; ANNULATION; ALDEHYDE; ACCESS; BONDS;

D O I：

10.1021/acs.joc.0c00803

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here, we report the first synthesis of 2,3-disubstituted quinolines from anilines and aromatic or aliphatic epoxides. This reaction utilizes Sc(OTf)(3) as a Lewis acid and TEMPO as an oxygen scavenger. A wide variety of highly substituted quinolines were obtained with moderate to excellent yields (up to 96%).

引用

页码：6741 / 6746

页数：6

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