Synthesis and reactions of 4-trifluoromethyl-3-cyano pyridine-2(1H)-thione/one derivatives

被引：8

作者：

Rateb, Nora M. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12136, Egypt

来源：

JOURNAL OF SULFUR CHEMISTRY | 2011年 / 32卷 / 06期

关键词：

Green synthesis; grinding; 3-cyanopyridine-2(1H)thione/one; thieno[2,3-b]pyridine; pyridothienopyrimidine; pyrazolopyridine; pyridothienooxazinone; PYRIDOTHIENOPYRIMIDINES; CONDENSATION; PYRIDINE;

D O I：

10.1080/17415993.2011.628994

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4,4,4-Trifluoro-1-(thiophen-2-yl)butane-1,3-dione was reacted by grinding with cyanothioacetamide and cyanoacetamide under solvent-free conditions at 25 degrees C to give pyridine-2(1H)thione/one derivatives in excellent yields. These compounds were further reacted by grinding with different halogenated reagents to give 2-S/O-alkyl pyridine derivatives. The latter compounds were utilized for the synthesis of thieno[2,3-b] pyridine, pyrazolopyridine, pyridothienopyrimidine and pyridothienooxazinone derivatives. [GRAPHICS] .

引用

页码：611 / 622

页数：12

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