Tau Protein Aggregation in Alzheimer's Disease: Recent Advances in the Development of Novel Therapeutic Agents

被引:8
|
作者
Monteiro, Kadja L. C. [1 ]
Alcantara, Marcone G. dos S. [1 ]
de Aquino, Thiago M. [2 ]
da Silva-Junior, Edeildo F. [2 ]
机构
[1] Univ Fed Alagoas, Inst Pharmaceut Sci, Lab Med Chem, Maceio, Alagoas, Brazil
[2] Univ Fed Alagoas, Chem & Biotechnol Inst, Maceio, Alagoas, Brazil
关键词
Alzheimer's disease; tau protein; aggregation inhibitors; neurodegeneration; phenothiazines; molecule inhibitors; PAIRED HELICAL FILAMENTS; METHYLENE-BLUE; INHIBITOR THERAPY; AMYLOID-BETA; DOUBLE-BLIND; IN-VITRO; FIBRILLIZATION; MODEL; HYPERPHOSPHORYLATION; POLYPHENOLS;
D O I
10.2174/1381612826666200414164038
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Major research in Alzheimer's disease (AD) related to disease-modifying agents is concentrated on pharmacological approaches related to diagnostic markers, neurofibrillary tangles and amyloid plaques. Although most studies focus on anti-amyloid strategies, investigations on tau protein have produced significant advances in the modulation of the pathophysiology of several neurodegenerative diseases. Since the discovery of phenothiazines as tau protein aggregation inhibitors (TAGIs), many additional small molecule inhibitors have been discovered and characterized in biological model systems, which exert their interaction effects by covalent and noncovalent means. In this paper, we summarize the latest advances in the discovery and development of tau aggregation inhibitors using a specialized approach in their chemical classes. The design of new TAGIs and their encouraging use in in vivo and clinical trials support their potential therapeutic use in AD.
引用
收藏
页码:1682 / 1692
页数:11
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