One-pot multicoupling reaction of silylcopper reagents, organolithium compounds and α,β-unsaturated nitriles

被引：5

作者：

Pulido, Francisco J. ^{[1
]}

Barbero, Asuncion ^{[1
]}

Blanco, Yolanda ^{[1
]}

机构：

[1] Univ Valladolid, Fac Ciencias, Dept Quim Organ, E-47011 Valladolid, Spain

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 05期

关键词：

DOUBLE NUCLEOPHILIC-ADDITION; DIMETALLIC ORGANIC-COMPOUNDS; ORGANOZINC COMPOUNDS; ZINC; ALLENE; CYCLOPENTANE; ALLYLSILANES; OXIDATION; COPPER; SCOPE;

D O I：

10.1039/c0ob00775g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The silylcupration of allene using a lower order silylcopper species gives an allylsilane-vinyl copper intermediate 2 which, in conjunction with an organolithium reagent, is able to participate in a one-pot multicoupling reaction with alpha,beta-unsaturated nitriles. The scope of this tandem reaction is studied and a possible mechanism pathway is outlined.

引用

页码：1454 / 1458

页数：5

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