Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms

被引：57

作者：

Stanzione, Rosita ^{[1
]}

Cotugno, Maria ^{[1
]}

Bianchi, Franca ^{[1
]}

Marchitti, Simona ^{[1
]}

Forte, Maurizio ^{[1
]}

Volpe, Massimo ^{[1
,2
]}

Rubattu, Speranza ^{[1
,2
]}

机构：

[1] IRCCS Neuromed, Via Atinense 18, I-86077 Pozzilli Is, Italy

[2] Sapienza Univ Rome, Sch Med & Psychol, Dept Clin & Mol Med, I-00189 Rome, Italy

来源：

GENES | 2020年 / 11卷 / 01期

关键词：

ischemic stroke; epigenetic; DNA methylation; histone modification; miRNA; lncRNA; LONG NONCODING RNA; DNA METHYLATION; GENE-EXPRESSION; UNCOUPLING PROTEIN-2; HISTONE DEACETYLASES; VASCULAR RECURRENCE; PROTECTS NEURONS; APOLIPOPROTEIN-E; RISK-FACTOR; POLYMORPHISMS;

D O I：

10.3390/genes11010089

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epigenetics is the branch of molecular biology that studies modifications able to change gene expression without altering the DNA sequence. Epigenetic modulations include DNA methylation, histone modifications, and noncoding RNAs. These gene modifications are heritable and modifiable and can be triggered by lifestyle and nutritional factors. In recent years, epigenetic changes have been associated with the pathogenesis of several diseases such as diabetes, obesity, renal pathology, and different types of cancer. They have also been related with the pathogenesis of cardiovascular diseases including ischemic stroke. Importantly, since epigenetic modifications are reversible processes they could assist with the development of new therapeutic approaches for the treatment of human diseases. In the present review article, we aim to collect the most recent evidence concerning the impact of epigenetic modifications on the pathogenesis of ischemic stroke in both animal models and humans.

引用

页数：13

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