Intrahepatic cholestasis of pregnancy: Recent advances

被引：53
|
作者：
Ovadia, Caroline [1 ]
Williamson, Catherine [1 ]
机构：
[1] Kings Coll London, Womens Hlth Acad Ctr, London, England
来源：
CLINICS IN DERMATOLOGY | 2016年 / 34卷 / 03期
关键词：
URSODEOXYCHOLIC ACID TREATMENT; ADENOSYL-L-METHIONINE; SALT EXPORT PUMP; PROGESTERONE METABOLITES; BILE-ACIDS; OBSTETRIC CHOLESTASIS; DOUBLE-BLIND; WOMEN; PRURITUS; MECHANISMS;
D O I：
10.1016/j.clindermatol.2016.02.004
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Intrahepatic cholestasis of pregnancy, also known as obstetric cholestasis, is a pruritic condition of pregnancy characterized by an underlying elevation in circulating bile acids and liver derangement, and associated with adverse fetal outcomes, such as preterm labor and stillbirth. Limited understanding of the underlying pathophysiology and mechanisms involved in adverse outcomes has previously restricted treatment options and pregnancy management. Recent advances in these research fields provide tantalizing targets to improve the care of pregnant women affected by this condition. (C) 2016 Elsevier Inc. All rights reserved.
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收藏
页码：327 / 334
页数：8
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