GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasing

被引：50
|
作者：
Sun, Liping [1 ,3 ,4 ]
Jin, Hao [1 ,3 ,4 ]
Li, Hui [2 ,3 ,4 ]
机构：
[1] Tianjin Med Univ Canc Inst & Hosp, Dept Immunol, Tianjin, Peoples R China
[2] Tianjin Med Univ Canc Inst & Hosp, Dept Gastrointestinal Canc Biol, Tianjin, Peoples R China
[3] Key Lab Canc Immunol & Biotherapy, Tianjin, Peoples R China
[4] Natl Clin Res Ctr Canc, Tianjin, Peoples R China
来源：
ONCOTARGET | 2016年 / 7卷 / 27期
关键词：
regulatory T cells; glycoprotein A repetitions predominant; transforming growth factor beta; GROWTH-FACTOR-BETA; IMMUNOLOGICAL SELF-TOLERANCE; LATENT TGF-BETA-1/GARP COMPLEX; INDUCE FOXP3 EXPRESSION; TOLL-LIKE RECEPTORS; HUMAN TREG; SUPERFAMILY MEMBERS; SIGNALING PATHWAYS; ACTIVE TGF-BETA-1; DENDRITIC CELLS;
D O I：
10.18632/oncotarget.8753
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
There are many molecules that define regulatory T cells (Tregs) phenotypically and functionally. Glycoprotein A repetitions predominant (GARP) is a transmembrane protein containing leucine rich repeats. Recently, GARP is found to express highly on the surface of activated Tregs. The combination of GARP and other surface molecules isolates Tregs with higher purity. Besides, GARP is a cell surface molecule of Tregs that maintains their regulatory function and homeosatsis. GARP has also been proved to promote the activation and secretion of transforming growth factor beta (TGF-beta()). Moreover, its potential value in cancer immunotherapy is also discussed in this work.
引用
收藏
页码：42826 / 42836
页数：11
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