Role of cancer stem cell marker CD44 in gastric cancer: a meta-analysis

被引：0
|
作者：
Wang, Wei [1 ]
Dong, Li-Ping [2 ]
Zhang, Ning [1 ]
Zhao, Cheng-Hai [1 ]
机构：
[1] China Med Univ, Dept Pathophysiol, Coll Basic Med Sci, Shenyang 110001, Peoples R China
[2] Lib China Med Univ, Shenyang 110001, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2014年 / 7卷 / 12期
基金：
中国国家自然科学基金;
关键词：
CD44; gastric cancer; metastasis; tumorigenesis; invasion; LYMPH-NODE METASTASIS; DE-NOVO EXPRESSION; STAGE-II; CARCINOMA; VARIANTS; INVASION; RECEPTOR; TUMOR; MMP-7; CD133;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cluster of differentiation 44 (CD44), a principal cell surface receptor for hyaluronic acid, has been implicated in tumorigenesis and metastasis. However, the relationship between CD44 expression and the patients with gastric cancer remains controversial. A meta-analysis was performed to quantitatively review the correlation of CD44 expression with the clinicopathological data of the patients with gastric cancer. We conducted a final analysis of the patients from 18 studies. Combined odds ratios (OR) suggested that CD44 expression was related with stage, tumor size, and LN metastasis of gastric cancer, and CD44v6 was related with LN metastasis, lymphatic invasion, and venous invasion. Our results suggested that CD44 and CD44v6 expression could be used to predict the metastasis of gastric cancer.
引用
收藏
页码：5059 / 5066
页数：8
相关论文
共 50 条
  • [1] The prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis
    Jiaying Lin
    Ding Ding
    [J]. Cancer Cell International, 17
  • [2] The prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis
    Lin, Jiaying
    Ding, Ding
    [J]. CANCER CELL INTERNATIONAL, 2017, 17
  • [3] Prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis
    Shi, Y. Y.
    Jiang, H.
    [J]. GENETICS AND MOLECULAR RESEARCH, 2016, 15 (03)
  • [4] The prognostic value of CD44 expression in gastric cancer: A meta-Analysis
    Chen, Yansu
    Fu, Ziyi
    Xu, Sujuan
    Xu, Ye
    Xu, Pengfei
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2014, 68 (06) : 693 - 697
  • [5] Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44
    Takaishi, Shigeo
    Okumura, Tomoyuki
    Tu, Shuiping
    Wang, Sophie S. W.
    Shibata, Wataru
    Vigneshwaran, Ramanathan
    Gordon, Shanisha A. K.
    Shimada, Yutaka
    Wang, Timothy C.
    [J]. STEM CELLS, 2009, 27 (05) : 1006 - 1020
  • [6] Role of CD44 as a marker of cancer stem cells in head and neck cancer
    Trapasso, Serena
    Allegra, Eugenia
    [J]. BIOLOGICS-TARGETS & THERAPY, 2012, 6 : 379 - 383
  • [7] CD44 and CD133 as Cancer Stem Cell Markers for Gastric Cancer
    Lee, Hyun-Joo
    Choi, Young-Sil
    Kim, Sung-Joo
    Moon, Hyoun Jong
    [J]. JOURNAL OF GASTRIC CANCER, 2010, 10 (03) : 99 - 105
  • [8] CD44 family proteins in gastric cancer: a meta-analysis and narrative review
    Wu, Ying
    Li, Zhi
    Zhang, Chenlu
    Yu, Kai
    Teng, Zan
    Zheng, Guoliang
    Wang, Shuang
    Liu, Yunpeng
    Cui, Lei
    Yu, Xiaosong
    [J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (03): : 3595 - U1695
  • [9] Proteomic analysis of CD44(+) and CD44(-) gastric cancer cells
    Yu, Dayeon
    Shin, Hyun-Soo
    Choi, Go
    Lee, Yong Chan
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2014, 396 (1-2) : 213 - 220
  • [10] Proteomic analysis of CD44(+) and CD44(−) gastric cancer cells
    Dayeon Yu
    Hyun-Soo Shin
    Go Choi
    Yong Chan Lee
    [J]. Molecular and Cellular Biochemistry, 2014, 396 : 213 - 220
12345