Eculizumab: A Guide to its Use in Paroxysmal Nocturnal Hemoglobinuria

被引：8
|
作者：
Keating, Gillian M. [1 ]
Lyseng-Williamson, Katherine A. [1 ]
McKeage, Kate [1 ]
机构：
[1] Adis Int Ltd, Auckland 10, New Zealand
来源：
BIODRUGS | 2012年 / 26卷 / 02期
关键词：
COMPLEMENT INHIBITOR ECULIZUMAB;
D O I：
10.2165/11208420-000000000-00000
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The targeted terminal complement inhibitor eculizumab (Soliris (R)) reduces intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH), as well as stabilizing hemoglobin levels, improving fatigue and health-related quality of life, and reducing the requirement for packed red cell transfusions. Eculizumab is generally well tolerated in patients with PNH, although the risk of Neisseria meningitidis infection is increased with eculizumab, meaning that patients must be vaccinated.
引用
收藏
页码：125 / 130
页数：6
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