A pancreatic extract-enriched diet improves the nutritional status of aged rats

被引:9
|
作者
Chambon-Savanovitch, C
Felgines, C
Walrand, S
Raul, F
Zarrabian, S
Meunier, MT
Farges, MC
Cynober, L
Vasson, MP [1 ]
机构
[1] Human Nutr Res Ctr, EA 2416, Sch Pharm, Lab Biochem Mol Biol & Nutr, Clermont Ferrand, France
[2] IRCAD, CJF INSERM 95 09, Strasbourg, France
[3] R Debre Hosp, INSERM, Paris, France
来源
JOURNAL OF NUTRITION | 2001年 / 131卷 / 03期
关键词
rats; aging; malnutrition; casein hydrolysate; pancreatic extract;
D O I
10.1093/jn/131.3.813
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Correction of the malnourished state, particularly common and severe in elderly people, is often unsuccessful. To improve the efficiency of realimentation, we evaluated the nutritional effect of a pancreatic extract (PE)-enriched diet in malnourished aged rats. Sprague-Dawley male rats were randomly assigned to 6 groups as follows: 1 group of control rats had free access to the diet for 12 wk (C group) and 5 groups were 50% food restricted for the same period, One food-restricted group was then killed (R group) and the 4 remaining groups were refed for 1 wk using a standard diet enriched either with two different doses of a pancreatic extract (2.4 or 4.8 g/d in PE1 and PE2 groups, respectively) or with an isonitrogenous casein hydrolysate (CH1 and CH2 groups, respectively). Profound alterations induced by food restriction (FR) were moderately corrected by refeeding, except nitrogen balance, which was reestablished in rats refed ail diets (P < 0.01- vs, R), Supplementation of the food ration with a pancreatic extract clearly improved recovery. Indeed, body weight gain, both jejunal and ileal trophicity [jejunum: total height, PE2: 849 +/- 45 <mu>m vs. CH2: 768 +/- 17 mum (P < 0.05); protein content, PE2: 69.9 +/- 5.7 mg vs. CH2: 56.4 +/- 4.8 mg (P < 0.01)] and nonspecific immune response in terms of H2O2 production by polymorphonuclear neutrophils and tumor necrosis factor alpha (TNF-alpha) by macrophages (PE2, 20.7 +/- 4.7 vs. CH2, 8.7 +/- 2.3, P < 0.05) were improved in rats fed PE2. A pancreatic extract could improve the efficiency of realimentation in malnourished aged rats.
引用
收藏
页码:813 / 819
页数:7
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