Synthesis of hyaluronic acid hydrogels by crosslinking the mixture of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid with 1,4-butanediol diglycidyl ether

被引：58

作者：

Xue, Yu ^{[1
]}

Chen, Hongyue ^{[1
]}

Xu, Chao ^{[1
]}

Yu, Dinghua ^{[1
]}

Xu, Huajin ^{[1
]}

Hu, Yi ^{[1
]}

机构：

[1] Nanjing Tech Univ, Sch Pharmaceut Sci, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Peoples R China

来源：

RSC ADVANCES | 2020年 / 10卷 / 12期

基金：

中国国家自然科学基金;

关键词：

DRUG-DELIVERY; POLYSACCHARIDE; COMPLEXES; SCAFFOLDS;

D O I：

10.1039/c9ra09271d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

High molecular weight hyaluronic acid (HMW-HA) and low molecular weight hyaluronic acid (LMW-HA) were mixed at different ratios and cross-linked with 1,4-butanediol diglycidyl ether (BDDE) to prepare five hyaluronic acid hydrogels A-E. Enzymolysis stability, swelling rate, crosslinking degree, rheological characteristics, BDDE residual rate, surface microstructure, and cytotoxicity of different hydrogels were investigated. The results showed that hydrogel B obtained by 10% HA (w/v, HMW-HA and LMW-HA having a mass ratio of 4 : 1) crosslinking with 1% BDDE (v/v) had stronger in vitro anti-degradation ability, better mechanical properties and lower cytotoxicity than those prepared by mixing in different proportions. Hydrogel B has potential applications in regenerative medicine and tissue engineering.

引用

页码：7206 / 7213

页数：8

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