Recognition of "mirror-image" DNA by small molecules

被引：18
|
作者：
Dose, Christian
Ho, Dominik
Gaub, Hermann E.
Dervan, Peter B. [1 ]
Albrecht, Christian H.
机构：
[1] CALTECH, Dept Chem & Chem Engn, Pasadena, CA 91125 USA
[2] Univ Munich, Lehrstuhl Angew Phys, D-80799 Munich, Germany
[3] Univ Munich, Ctr Nanosci, D-80799 Munich, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 44期
关键词：
chiral resolution; DNA recognition; nanotechnology; polyamides; single-molecule studies;
D O I：
10.1002/anie.200703007
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
May the force be with you: "Mirror-image" hairpin polyamides distinguish the L enantiomer of DNA (L-DNA) in the presence of natural DNA (D-DNA). This specificity is investigated by a molecular force balance at a single-molecule level. The "DNA balance" allows the measurement of rupture forces of match/mismatch diastereomeric complexes in a single experiment. (Chemical Equation Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：8384 / 8387
页数：4
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