Potential role of lipoxin in the management of COVID-19: a narrative review

被引：28

作者：

Batiha, Gaber El-Saber ^{[1
]}

Al-Gareeb, Ali, I ^{[2
]}

Elekhnawy, Engy ^{[3
]}

Al-Kuraishy, Hayder M. ^{[2
]}

机构：

[1] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, Albeheira, Egypt

[2] Al Mustansiriyah Univ, Coll Med, Dept Pharmacol Toxicol & Med, Baghdad 14132, Iraq

[3] Tanta Univ, Fac Pharm, Pharmaceut Microbiol Dept, Tanta 31527, Egypt

来源：

INFLAMMOPHARMACOLOGY | 2022年 / 30卷 / 06期

关键词：

Arachidonic acid; COVID-19; Inflammation; Lipoxins; SARS-CoV-2; ASPIRIN-TRIGGERED LIPOXIN; ACTIVATED PROTEIN-KINASES; FORMYL PEPTIDE RECEPTOR; ACUTE LUNG INJURY; LIPID MEDIATORS; MOUSE MODEL; A(4); RESOLUTION; INFLAMMATION; A4;

D O I：

10.1007/s10787-022-01070-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection leads to the development of coronavirus disease 2019 (COVID-19), which causes endothelial dysfunction (ED), oxidative stress (OS), and inflammatory disorders. These changes cause hypoxia and cytokine storm with the development of cardio-pulmonary complications. Bioactive lipids and other polyunsaturated fatty acids participate in a vital role in the SARS-CoV-2 infection process. One of these mediators is the anti-inflammatory compound, lipoxin (LX). LXs are produced from arachidonic acid (AA) by collaboration between 5-lipoxygenase (5-LO) and 12-15 LO during cell interactions. Thus, our goal was to review the probable role of LXs in COVID-19 regarding the effects of LXs on the inflammatory signaling pathways that are linked with COVID-19 pathogenesis and complications.

引用

页码：1993 / 2001

页数：9

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