Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma

被引：33

作者：

Shi Hai-yun ^{[1
]}

Lv Fu-jing ^{[1
]}

Zhu Sheng-tao ^{[1
]}

Wang Qing-gang ^{[1
]}

Zhang Shu-tian ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Friendship Hosp, Dept Gastroenterol, Beijing Digest Dis Ctr, Beijing 100050, Peoples R China

来源：

CANCER LETTERS | 2011年 / 309卷 / 01期

关键词：

ESCC; COX-2; 5-LOX; Nude mice; COLON-CANCER; ARACHIDONIC-ACID; SELECTIVE COX-2; BREAST-CANCER; 5-LIPOXYGENASE; CYCLOOXYGENASE-2; EXPRESSION; CELECOXIB; APOPTOSIS; PATHWAY;

D O I：

10.1016/j.canlet.2011.05.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

COX-2 and 5-LOX are up-regulated in ESCC. This study aims to determine the efficacy of COX-2 inhibitor, 5-LOX inhibitor and their combination on ESCC. Nimesulide can suppress cell growth and promote apoptosis, accompanied with a decrease of PGE(2) production. AA861 has the similar effect with a down-regulation of LTB(4). In animal experiment, the tumor volumes in drug-treated groups were significantly smaller with the lowest rates of Ki-67 positive cells. In conclusion, either COX-2 inhibitor or 5-LOX inhibitor can suppress ESCC. Dual inhibition of COX-2 and 5-LOX pathway may present a superior anticancer efficacy to either inhibition of COX-2 or 5-LOX alone. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：19 / 26

页数：8

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