Amino-Functionalized Oligonucleotides with Peptide Internucleotide Linkages

被引：0
|
作者：
Varizhuk, Anna M. [1 ]
Kochetkova, Svetlana V. [1 ]
Fedotov, Alexander U. [1 ]
Kolganova, Natalia A. [1 ]
Timofeev, Edward N. [1 ]
Florentiev, Vladimir L. [1 ]
机构：
[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia
来源：
LETTERS IN ORGANIC CHEMISTRY | 2012年 / 9卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
Analogs; hybridization; oligonucleotides; peptide internucleotide linkages; synthesis; thermal stability; ANTISENSE OLIGONUCLEOTIDES; DNA; DUPLEXES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Oligonucleotide analogs with L- and D-lysine residues incorporated in internucleotide linkages were synthesized and their affinity toward complementary DNA was studied. Stability of the duplexes formed by the modified oligonucleotides and their wild-type complements appeared to be close to that of the isosequential unmodified duplex, oligonucleotides carrying D-lysine residues forming generally more stable duplexes than L-lysine derivatives.
引用
收藏
页码：106 / 113
页数：8
相关论文
共 50 条
  • [1] Oligonucleotide Analogs with Peptide Internucleotide Linkages
    Varizhuk, Anna
    Kochetkova, Svetlana
    Kolganova, Natalia
    Timofeev, Edward
    Florentiev, Vladimir
    [J]. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2011, 30 (01): : 31 - 48
  • [2] ENZYMATIC-SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING METHYLPHOSPHONATE INTERNUCLEOTIDE LINKAGES
    HIGUCHI, H
    ENDO, T
    KAJI, A
    [J]. BIOCHEMISTRY, 1990, 29 (37) : 8747 - 8753
  • [3] A TEMPORARY PROTECTING GROUP FOR THE SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING MODIFIED INTERNUCLEOTIDE LINKAGES
    SAMOSHIN, VV
    KHUDYAKOV, YE
    SMIRNOV, VD
    [J]. BIOORGANICHESKAYA KHIMIYA, 1991, 17 (02): : 241 - 245
  • [4] Oligonucleotides containing a peptide internucleotide linkage. A novel class of modified oligonucleotides
    Varizhuk, A. M.
    Kochetkova, S. V.
    Kolganova, N. A.
    Timofeev, E. N.
    Florentiev, V. L.
    [J]. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2010, 36 (04) : 528 - 531
  • [5] Oligonucleotides containing a peptide internucleotide linkage. A novel class of modified oligonucleotides
    A. M. Varizhuk
    S. V. Kochetkova
    N. A. Kolganova
    E. N. Timofeev
    V. L. Florentiev
    [J]. Russian Journal of Bioorganic Chemistry, 2010, 36 : 528 - 531
  • [6] Amino-Functionalized Pillar[5]arene
    Strutt, Nathan L.
    Zhang, Huacheng
    Schneebeli, Severin T.
    Stoddart, J. Fraser
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (35) : 10996 - 11004
  • [7] The reaction of an amino-functionalized DPP with acrolein
    Yamagata, Takuya
    Kaneko, Rinpei
    [J]. TETRAHEDRON LETTERS, 2022, 100
  • [8] Palladium complexes with amino-functionalized silica
    Donskaya, ND
    Zaitsev, VN
    Skopenko, VV
    [J]. ZHURNAL NEORGANICHESKOI KHIMII, 2000, 45 (03): : 464 - 468
  • [9] Borane complex of amino-functionalized phosphine
    Reznicek, Tomas
    Dostal, Libor
    Ruzicka, Ales
    Jambor, Roman
    [J]. MAIN GROUP METAL CHEMISTRY, 2012, 35 (5-6) : 129 - 133
  • [10] Tuning the hybridization properties of modified oligonucleotides: from flexible to conformationally constrained phosphonate internucleotide linkages
    Pav, Ondrej
    Barvik, Ivan
    Liboska, Radek
    Petrova, Magdalena
    Simak, Ondrej
    Rosenbergova, Sarka
    Novak, Pavel
    Budesinsky, Milos
    Rosenberg, Ivan
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 15 (03) : 701 - 707
12345