Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission

被引：193
|
作者：
Blier, P [1 ]
Piñeyro, G [1 ]
El Mansari, M [1 ]
Bergeron, R [1 ]
De Montigny, C [1 ]
机构：
[1] McGill Univ, Neurobiol Psychiat Unit, Montreal, PQ H3A 1A1, Canada
来源：
ADVANCES IN SEROTONIN RECEPTOR RESEARCH: MOLECULAR BIOLOGY, SIGNAL TRANSDUCTION, AND THERAPEUTICS | 1998年 / 861卷
关键词：
D O I：
10.1111/j.1749-6632.1998.tb10192.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A very important element controlling serotonin (5-HT) release throughout the brain is the 5-HT1A autoreceptor present on the soma and dendrites of 5-HT neurons since it exerts a negative feedback influence on their firing activity, This 5-HT1A autoreceptor receives an increased activation by endogenous 5-HT at the beginning of a treatment with a selective 5-HT reuptake inhibitor (SSRI) and, consequently, a decreased 5-HT neuronal firing activity is obtained. As the SSRI treatment is prolonged, the 5-HT1A autoreceptor desensitizes and firing activity is restored in the presence of the SSRI, That this adaptive change underlies, at least in part, the delayed therapeutic effect of SSRI in major depression is supported by the acceleration of the antidepressant response by the concomitant administration of the 5-HT1A autoreceptor antagonist pindolol with SSRIs.
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页码：204 / 216
页数：13
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