Radiation-induced "Bystander" effect

Research data on the developmental mechanisms and subjects and methods of studying a nontarget radiation phenomenon, called the "bystander effect," are generalized and analyzed, and its role in radiation-induced genomic instability and oncogenesis is studied. A natural model system is developed for identifying radiation-induced cytogenetic bystander effect in human somatic cells. These cells should be collected from a population of peripheral blood lymphocytes that has been irradiated in vitro or in vivo (as the source of the damaging signal) along with a population of nonirradiated lymphocytes of individuals of the opposite sex, which are used as "bystanders.".