Synthesis and biological evaluation of N-(substituted phenyl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamides as antimicrobial, antidepressant, and anticonvulsant agents

被引：8
|
作者：
Shruthi, N. [1 ]
Poojary, Boja [1 ]
Kumar, Vasantha [1 ]
Prathibha, A. [1 ]
Hussain, Mumtaz Mohammed [2 ]
Revanasiddappa, B. C. [3 ]
Joshi, Himanshu [3 ]
机构：
[1] Mangalore Univ, Dept Chem, Mangalagangothri 574199, Karnataka, India
[2] SJM Coll Pharm, Dept Pharmaceut Chem, Chitradurga 575501, Karnataka, India
[3] NGSM Inst Pharmaceut Sci, Dept Pharmacol, Mangalore 575018, Karnataka, India
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2015年 / 41卷 / 02期
关键词：
1,2,4]triazino[5,6-b]indoles; antimicrobial activities; antidepressant activities; anticonvulsant activities; DERIVATIVES; DEPRESSION; INHIBITORS;
D O I：
10.1134/S1068162015020144
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new series of N-Aryl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamides were synthesized by condensation of tricyclic compound 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione with chloro N-phenylacetamides. The tricyclic compound was obtained by condensation of Isatin with thiosemicarbazide. Chloro N-phenylacetamides were obtained from different substituted anilines. Their structures were characterized by IR, H-1 NMR, LC-MS and elemental analyses. Newly synthesized compounds were screened for antimicrobial, antidepressant and anticonvulsant activities. Preliminary results indicated that most of the compounds showed lesser MIC value than the standard drug used when tested for antimicrobial activity. Some of the compounds were endowed with very good antidepressant and anticonvulsant activity.
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收藏
页码：223 / 230
页数：8
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