Olanzapine treatment after clozapine-induced granulocytopenia in 3 patients

被引：16
|
作者：
Swartz, JR [1 ]
Ananth, J [1 ]
Smith, MW [1 ]
Burgoyne, KS [1 ]
Gadasally, R [1 ]
Arai, Y [1 ]
机构：
[1] Harbor UCLA Med Ctr, Dept Psychiat, Torrance, CA 90509 USA
来源：
JOURNAL OF CLINICAL PSYCHIATRY | 1999年 / 60卷 / 02期
关键词：
D O I：
10.4088/JCP.v60n0209
中图分类号：
B849 [应用心理学];
学科分类号：
040203 ;
摘要：
Background: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem. Case reports: We report 3 patients with chronic schizophrenia who had previously stopped clozapine due to hematologic side effects. The patients evidenced improvement with olanzapine that equated to 16- to 31-point decreases in rating scale scores during I-year follow-up without any hematologic abnormalities. Conclusion: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.
引用
收藏
页码：119 / 121
页数：3
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