Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice

被引：45
|
作者：
Immel, Timo A. [1 ,2 ]
Groth, Ulrich [1 ,2 ]
Huhn, Thomas [1 ,2 ]
Oehlschlaeger, Peter [3 ]
机构：
[1] Univ Konstanz, Dept Chem, Constance, Germany
[2] Univ Konstanz, Konstanz Res Sch Chem Biol, Constance, Germany
[3] Univ Konstanz, Dept Immunol, Constance, Germany
来源：
PLOS ONE | 2011年 / 6卷 / 03期
关键词：
PLATINUM COMPLEXES; TITANOCENE DICHLORIDE; ANTICANCER DRUGS; CANCER-TREATMENT; METAL-COMPLEXES; CERVICAL-CANCER; HYDROLYSIS; DNA; VACCINATION; WOMEN;
D O I：
10.1371/journal.pone.0017869
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The anticancer activity of titanium complexes has been known since the groundbreaking studies of Kopf and Kopf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
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页数：7
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