Microbubbles as Ultrasound Contrast Agents for Molecular Imaging: Preparation and Application

被引：141
|
作者：
Unnikrishnan, Sunil [1 ,2 ]
Klibanov, Alexander L. [1 ,2 ]
机构：
[1] Univ Virginia, Cardiovasc Div, Cardiovasc Res Ctr, Charlottesville, VA 22098 USA
[2] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22098 USA
来源：
AMERICAN JOURNAL OF ROENTGENOLOGY | 2012年 / 199卷 / 02期
关键词：
angiogenesis; contrast agents; inflammation; microbubbles; molecular imaging; ultrasound; TUMOR ANGIOGENESIS; P-SELECTIN; POLY(ETHYLENE GLYCOL); ENHANCED ULTRASOUND; TARGETED DELIVERY; VASA VASORUM; IN-VIVO; INFLAMMATION; ADHESION; BINDING;
D O I：
10.2214/AJR.12.8826
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
OBJECTIVE. The purpose of this review is to describe trends in microbubble application in molecular imaging. CONCLUSION. Microbubbles are used for contrast ultrasound imaging as blood-pool agents in cardiology and radiology. Their promise as targeted agents for molecular imaging is now being recognized. Microbubbles can be functionalized with ligand molecules that bind to molecular markers of disease. Potential clinical applications of molecular imaging with microbubble-based ultrasound contrast agents are in the monitoring of the biomarker status of vascular endothelium, visualizing tumor vasculature, and imaging inflammation and ischemia-reperfusion injury zones and thrombi.
引用
收藏
页码：292 / 299
页数：8
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