Lipoprotein oxidation and atherosclerosis

被引：118
|
作者：
Young, IS [1 ]
McEneny, J [1 ]
机构：
[1] Royal Grp Hosp, Inst Clin Sci, Dept Clin Biochem, Belfast BT12 6BJ, Antrim, North Ireland
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2001年 / 29卷
关键词：
antioxidants; atherogenesis; LDL; lipid peroxidation;
D O I：
10.1042/0300-5127:0290358
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipoprotein oxidation is a key early stage in the development of atherosclerosis. Oxidation of low-density lipoprotein (LDL) is initiated by both enzyme-mediated and non-enzymic mechanisms in vivo, and oxidized LDL has many atherogenic properties. Oxidation of LDL in vivo is likely to be influenced by local environmental factors, such as pH. The composition of LDL is also important, including such factors as antioxidant content, fatty acid composition and particle size.
引用
收藏
页码：358 / 362
页数：5
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