Synthesis of diether-linked cationic lipids for gene delivery

被引：30
|
作者：
Ren, T [1 ]
Liu, D [1 ]
机构：
[1] Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 09期
关键词：
D O I：
10.1016/S0960-894X(99)00187-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Quaternary ammonium lipids 1b-d, with diether linkages between hydrocarbon chains and butane or hexane backbone, were synthesized for cationic liposome-mediated gene delivery. The synthetic strategy of using C-4 or C-6 synthon permits the achievement of the variation of the hydrophobic domain as well as changes of space between the quaternary ammonium head and the hydrophobic domain in the diether-linked cationic lipids. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1247 / 1250
页数：4
相关论文
共 50 条
  • [1] Synthetic diether-linked cationic lipids for gene delivery
    Liu, DL
    Qiao, WH
    Li, ZS
    Zhang, SB
    Cheng, LB
    Jin, K
    [J]. CHEMICAL BIOLOGY & DRUG DESIGN, 2006, 67 (03) : 248 - 251
  • [2] PROPERTIES OF CURED DIETHER-LINKED PHTHALONITRILE RESINS
    TING, RY
    KELLER, TM
    MARULLO, NP
    PEYSER, P
    PRICE, TR
    PORANSKI, CF
    [J]. SAMPE QUARTERLY-SOCIETY FOR THE ADVANCEMENT OF MATERIAL AND PROCESS ENGINEERING, 1981, 12 (04): : 1 - 3
  • [3] PROPERTIES OF CURED DIETHER-LINKED PHTHALOCYANINE RESINS
    KELLER, TM
    MARULLO, NP
    PEYSER, P
    PORANSKI, CF
    PRICE, TR
    TING, RY
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1981, 181 (MAR): : 89 - POLY
  • [4] CHARACTERIZATION OF THE CURE OF DIETHER-LINKED PHTHALONITRILE RESINS
    TING, RY
    KELLER, TM
    PRICE, TR
    PORANSKI, CF
    [J]. ACS SYMPOSIUM SERIES, 1982, 195 : 337 - 350
  • [5] Synthesis and characterization of a series of carbamate-linked cationic lipids for gene delivery
    Liu, DL
    Hu, JJ
    Qiao, WH
    Li, ZS
    Zhan, SB
    Cheng, LB
    [J]. LIPIDS, 2005, 40 (08) : 839 - 848
  • [6] Carbamate-linked cationic lipids for gene delivery
    Liu, Dongliang
    Qiao, Weihong
    Li, Zongshi
    Cui, Xiuyun
    Li, Kun
    Yu, Lihua
    Yan, Kelu
    Zhu, Limin
    Cheng, Lvbo
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (02) : 995 - 1005
  • [7] Synthesis and biological activity of carbamate-linked cationic lipids for gene delivery in vitro
    Zhi, Defu
    Zhang, Shubiao
    Qureshi, Farooq
    Zhao, Yinan
    Cui, Shaohui
    Wang, Bing
    Chen, Huiying
    Wang, Yinhuan
    Zhao, Defeng
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (11) : 3837 - 3841
  • [8] Synthesis and surface activity of diether-linked phosphoglycerols: Potential applications for exogenous lung surfactants
    Notter, Robert H.
    Wang, Zhongyi
    Wang, Zhengdong
    Davy, Jason A.
    Schwan, Adrian L.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (01) : 113 - 117
  • [9] Synthesis of carbamate-linked lipids for gene delivery
    Liu, DL
    Hu, JJ
    Qiao, WH
    Li, ZS
    Zhang, SB
    Cheng, LB
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (12) : 3147 - 3150
  • [10] Carbamate-linked cationic lipids with different hydrocarbon chains for gene delivery
    Shi, Jia
    Yu, Shijun
    Zhu, Jie
    Zhi, Defu
    Zhao, Yinan
    Cui, Shaohui
    Zhang, Shubiao
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 141 : 417 - 422
12345