A Modular Synthesis of the Rhazinilam Family of Alkaloids and Analogs Thereof

被引：4

作者：

Garcia-Ramirez, Jazmin ^{[1
]}

Gonzalez-Cortes, Luis A. ^{[1
]}

Miranda, Luis D. ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Ciudad De Mexico 04510, Mexico

来源：

ORGANIC LETTERS | 2022年

关键词：

H BOND ACTIVATION; CONCISE SYNTHESIS; (-)-RHAZINILAM;

D O I：

10.1021/acs.orglett.2c02446

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short, modular strategy for synthesizing three representative alkaloids of the (+/-)-rhazinilam family and 10 non-natural analogs is described. The protocol involves a radical addition/cyclization cascade reaction that assembles the tetrahydroindolizine system decorated with appropriate groups for a subsequent Pd-mediated cyclization, which generates the nine-membered lactam.

引用

页码：8093 / 8097

页数：5

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