Extremely small sample size in some toxicity studies: An example from the rabbit eye irritation test

被引：2
|
作者：
Liu, PT [1 ]
机构：
[1] US FDA, Ctr Food Safety & Appl Nutr, Div Math, Washington, DC 20204 USA
来源：
REGULATORY TOXICOLOGY AND PHARMACOLOGY | 2001年 / 33卷 / 02期
关键词：
multiple screening; sensitivity; specificity; false positive; false negative; mixture binomial; Bayes' theorem; regulatory decisions;
D O I：
10.1006/rtph.2000.1445
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
The conventional sample-size equations based on either the precision of estimation or the power of testing a hypothesis may not be appropriate to determine sample size for a "diagnostic" testing problem, such as the eye irritant Draize test. When the animals' responses to chemical compounds are relatively uniform and extreme and the objective is to classify a compound as either irritant or nonirritant, the test using just two or three animals may be adequate.
引用
收藏
页码：187 / 191
页数：5
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