Dissecting cellular components of the secretory pathway in filamentous fungi: insights into their application for protein production

被引：29
|
作者：
Shoji, Jun-ya [1 ]
Arioka, Manabu [1 ]
Kitamoto, Katsuhiko [1 ]
机构：
[1] Univ Tokyo, Dept Biotechnol, Bunkyo Ku, Tokyo 1138657, Japan
来源：
BIOTECHNOLOGY LETTERS | 2008年 / 30卷 / 01期
关键词：
Aspergillus; protein production; SNARE; vesicular trafficking;
D O I：
10.1007/s10529-007-9516-1
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Studies on protein production using filamentous fungi have mostly focused on improvement of the protein yields by genetic modifications such as overexpression. Recent genome sequencing in several filamentous fungal species now enables more systematic approaches based on reverse genetics and molecular biology of the secretion pathway. In this review, we summarize recent molecular-based advances in our understanding of vesicular trafficking in filamentous fungi, and discuss insights into their high secretion ability and application for protein production.
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收藏
页码：7 / 14
页数：8
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