Electrochemical studies on the permeable characteristics of thiol-modified double-stranded DNA self-assembled monolayers on gold

被引：9
|
作者：
Li, Zhiguo [1 ,2 ]
Niu, Tianxing [1 ,2 ]
Zhang, Zhenjiang [1 ,2 ,3 ]
Chen, Ran [1 ,2 ]
Feng, Guiying [1 ,2 ]
Bi, Shuping [1 ,2 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China
[2] Nanjing Univ, Key Lab MOE Life Sci, Nanjing 210093, Peoples R China
[3] Suzhou Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215006, Peoples R China
来源：
ANALYST | 2011年 / 136卷 / 10期
关键词：
SCANNING-TUNNELING-MICROSCOPY; ELECTRON-TRANSFER; CHARGE-TRANSPORT; OLIGONUCLEOTIDE MONOLAYERS; MOLECULAR-ORIENTATION; POLYCRYSTALLINE GOLD; IONIC PERMEABILITY; DOUBLE-LAYER; DS-DNA; HYBRIDIZATION;
D O I：
10.1039/c0an01032d
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In this article we studied the permeable characteristics of thiol-modified double-stranded DNA (ds-DNA) self-assembled monolayers (SAMs) on a gold substrate assembled under different NaCl concentrations by electrochemical methods. It was based on the inspection of five important parameters including interfacial capacitance (C), phase angle (Phi(1) (Hz)), ions transfer resistance (R-it*), current density difference (Delta j) and electron transfer rate (k(et)) through cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Three sections were included: (1) Investigation of the relationships of C, Phi(1) (Hz), R-it*, Delta j and k(et) with NaCl concentrations and comparison with the reports from literature. Experimental results showed that ds-DNA-SAMs were permeable films. (2) Construction of a simple model for exploring the permeable characteristics of ds-DNA-SAMs on gold. (3) Confirmation of the simple model by chronocoulometry (CC) and application of the model to explain the permeable mechanism. This study was significant for exploring the mechanism of electron transfer through the interior of ds-DNA duplex helix.
引用
收藏
页码：2090 / 2099
页数：10
相关论文
共 50 条
  • [1] Formation of self-assembled thiol-modified DNA monolayers on gold electrode
    Yau, HCM
    Yang, MS
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 214 : 100 - ANYL
  • [2] Thiol-modified phthalocyanines and their self-assembled monolayers on gold surfaces
    Li, ZY
    Lieberman, M
    [J]. FUNDAMENTAL AND APPLIED ASPECTS OF CHEMICALLY MODIFIED SURFACES, 1999, (235): : 24 - 35
  • [3] Exploration of the specific structural characteristics of thiol-modified single-stranded DNA self-assembled monolayers on gold by a simple model
    Li, Zhiguo
    Niu, Tianxing
    Zhang, Zhenjiang
    Chen, Ran
    Feng, Guiying
    Bi, Shuping
    [J]. BIOSENSORS & BIOELECTRONICS, 2011, 26 (11): : 4564 - 4570
  • [4] Adsorption kinetics and ligand-binding properties of thiol-modified double-stranded DNA on a gold surface
    Yang, MS
    Yau, HCM
    Chan, HL
    [J]. LANGMUIR, 1998, 14 (21) : 6121 - 6129
  • [5] Spin Selectivity in Electron Transmission Through Self-Assembled Monolayers of Double-Stranded DNA
    Goehler, B.
    Hamelbeck, V.
    Markus, T. Z.
    Kettner, M.
    Hanne, G. F.
    Vager, Z.
    Naaman, R.
    Zacharias, H.
    [J]. SCIENCE, 2011, 331 (6019) : 894 - 897
  • [6] Electrochemical determination of fisetin using gold electrodes modified with thiol self-assembled monolayers
    Maza, Eliana
    Fernandez, Hector
    Alicia Zon, Maria
    Beatriz Moressi, Marcela
    [J]. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2017, 790 : 1 - 10
  • [7] Electrochemical characteristics of thin nickel hexacyanoferrate films formed on gold and thiol self-assembled monolayers modified gold electrodes
    Zeng, BZ
    Zhao, FQ
    Ding, XG
    [J]. ANALYTICAL SCIENCES, 2001, 17 (02) : 259 - 264
  • [8] Electrochemical Characteristics of Thin Nickel Hexacyanoferrate Films Formed on Gold and Thiol Self-Assembled Monolayers Modified Gold Electrodes
    Baizhao Zeng
    Faqiong Zhao
    Xiaogang Ding
    [J]. Analytical Sciences, 2001, 17 : 259 - 264
  • [9] Electrochemical Studies of Derivatized Thiol Self-Assembled Monolayers on Gold Electrode in the Presence of Surfactants
    Liu Yang
    Wanzhi Wei
    Jianjun Xia
    Han Tao
    Pinghua Yang
    [J]. Analytical Sciences, 2005, 21 : 679 - 684
  • [10] Electrochemical studies of derivatized thiol self-assembled monolayers on gold electrode in the presence of surfactants
    Yang, L
    Wei, WZ
    Xia, JJ
    Tao, H
    Yang, PH
    [J]. ANALYTICAL SCIENCES, 2005, 21 (06) : 679 - 684
12345