Efficient synthesis of new 1-alkyl(aryl)-5-(3,3,3-trihalo-2-oxopropylidene)-1H-pyrrol-2(5H)-ones

被引：7

作者：

Flores, Alex F. C. ^{[1
]}

Pizzuti, Lucas ^{[2
]}

Piovesan, Luciana A. ^{[3
]}

Flores, Darlene C. ^{[1
]}

Malavolta, Juliana L. ^{[1
]}

Pereira, Claudio M. P. ^{[4
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, NUQUIMHE, BR-97105900 Santa Maria, RS, Brazil

[2] Fundacao Univ Fed Grande Dourados, BR-79804970 Dourados, MS, Brazil

[3] Univ Fed Rio de Janeiro, Fac Farm, Lab Avaliacao & Sintese Subst Bioat, LASSBio, BR-21941590 Rio De Janeiro, Brazil

[4] Univ Fed Pelotas, Inst Quim & Geociencias, BR-96010900 Pelotas, RS, Brazil

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 37期

关键词：

LACTONES;

D O I：

10.1016/j.tetlet.2010.07.073

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1-alkyl(aryl)-5-(3,3,3-trihalo-2-oxopropylidene)-1H-pyrrol-2(5H)-ones 5, 6a-d from 1-alkyl(aryl)-4-bromo-5-(3,3,3-trihalo-2-oxopropylidene)-1H-pyrrolidin-2-ones 3, 4a-d is reported. The 1-alkyl(aryl)-4-bromo-5-(3,3,3-trihalo-2-oxopropylidene)-1H-pyrrolidin-2-ones 3, 4a-d were obtained from regiospecific bromination of 1-alkyl(aryl)-5-(3,3,3-trihalo-2-oxopropylidene)-1H-pyrrolidin-2-ones 1, 2a-d with molecular bromine. The NMR and X-ray diffraction data showed that 1-alkyl(aryl)-5-(3,3,3-trihalo-2-oxopropylidene)-1H-pyrrolidin-2-ones were brominated at 4-position in the pyrrolidin-2-one ring. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4908 / 4910

页数：3

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