A Fast CEA Analyzer Prototype for Point of Care Testing

被引：0
|
作者：
Wang, Chua-Chin [1 ]
Liao, Chiang-Hsiang [1 ]
Chang, Chia-Ming
Lan, Je-Wei
Huang, I-Yu [1 ]
机构：
[1] Natl Sun Yat Sen Univ, Dept Elect Engn, Kaohsiung 80424, Taiwan
来源：
2014 IEEE INTERNATIONAL CONFERENCE ON ELECTRON DEVICES AND SOLID-STATE CIRCUITS (EDSSC) | 2014年
关键词：
CEA measurement; frequency-shift readout circuit; FPW; resonant frequency; point of care testing (POCT);
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
A CEA (carcinoembryonic antigen) concentration analyzer prototype using a pair of two-port FPW (flexural plate-wave) sensors is proposed in this paper. The proposed prototype utilizes a frequency-shift readout method based upon a peak detecting scheme to measure the resonant frequency shift. The frequency-shift readout circuit is integrated on silicon composed of a linear frequency generator, two peak detectors, two registers, and a subtractor. The frequency scanning range is from 0.9 MHz to 22.4 MHz according to the characteristics of the FPW biosensor. The sensitivity of the peak detector is 5 mV. The proposed frequency-shift readout circuit is verified by a PCB-based prototype, where the CEA serum titration is stabilized after 10 minutes and the linearity of the concentration vs. frequency shift is 97.72%.
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页数：2
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