Two New Phenolic Glycosides from Sorbus commixta

被引：7
|
作者：
Kim, Chung Sub [1 ]
Oh, Joonseok [2 ,3 ]
Subedi, Lalita [4 ,5 ]
Kim, Sun Yeou [4 ,5 ]
Choi, Sang Un [6 ]
Lee, Kang Ro [1 ]
机构：
[1] Sungkyunkwan Univ, Sch Pharm, Nat Prod Lab, Suwon 16419, South Korea
[2] Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06520 USA
[3] Yale Univ, Inst Chem Biol, West Haven, CT 06516 USA
[4] Gachon Univ, Gachon Inst Pharmaceut Sci, Incheon 21936, South Korea
[5] Gachon Univ, Coll Pharm, 191 Hambakmoero, Incheon 21936, South Korea
[6] Korea Res Inst Chem Technol, Daejeon 34114, South Korea
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2018年 / 66卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
Sorbus commixta; phenolic glycoside; DP4+; LIGNAN; CONSTITUENTS; BARK;
D O I：
10.1248/cpb.c18-00280
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
From the stem bark of Sorbus commixta, two new phenolic glycosides, sorcomisides A and B (1 and 2), were isolated along with 10 known compounds. The structures of the isolates were determined by analysis of one-dimensional and two-dimensional NMR (1D- and 2D-NMR) data and high resolution (HR)-MS, chemical reaction, and computational methods. All the isolated compounds (1-12) were tested for their neuroprotective, anti-inflammatory, and cytotoxic activities.
引用
收藏
页码：839 / 842
页数：4
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