Penaramides, which inhibit binding of omega-conotoxin GVIA to N-type Ca2+ channels, from the marine sponge Penares aff incrustans

被引：17

作者：

UshioSata, N

Matsunaga, S

Fusetani, N

Honda, K

Yasumuro, K

机构：

[1] UNIV TOKYO,GRAD SCH AGR LIFE SCI,LAB AQUAT NAT PROD CHEM,BUNKYO KU,TOKYO 113,JAPAN

[2] YAMANOUCHI PHARMACEUT CO LTD,INST DRUG DISCOVERY RES,TSUKUBA,IBARAKI 305,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 02期

关键词：

D O I：

10.1016/0040-4039(95)02134-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Penaramides which inhibit binding of omega-conotoxin GVIA to N-type Ca2+ channels have been isolated from the marine sponge Penares aff. incrustans and their structures determined by spectral and chemical methods to be bis-amides of an unusual polyamine. The proposed structures have been confirmed by a total synthesis of the simplest component, penaramide A.

引用

页码：225 / 228

页数：4

共 36 条

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