Recent developments in the isolation, biological function, biosynthesis, and synthesis of phenazine natural products

被引：155

作者：

Guttenberger, Nikolaus ^{[1
,2
]}

Blankenfeldt, Wulf ^{[3
,4
]}

Breinbauer, Rolf ^{[1
]}

机构：

[1] Graz Univ Technol, Inst Organ Chem, Stremayrgasse 9, A-8010 Graz, Austria

[2] Karl Franzens Univ Graz, Inst Chem Analyt Chem, Univ Pl 1, A-8010 Graz, Austria

[3] Helmholtz Ctr Infect Res, Struct & Funct Prot, Inhoffenstr 7, D-38124 Braunschweig, Germany

[4] Tech Univ Carolo Wilhelmina Braunschweig, Inst Biochem Biotechnol & Bioinformat, Spielmannstr 7, D-38106 Braunschweig, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2017年 / 25卷 / 22期

基金：

奥地利科学基金会;

关键词：

Antibiotics; Anticancer; Biofilm; Biosynthesis; Natural product; Phenazine; 4-COMPONENT DOMINO PROTOCOL; TETRAMETHYLPIPERIDINE-SUBSTITUTED PHENAZINES; PSEUDOMONAS-AERUGINOSA PYOCYANIN; ONE-POT SYNTHESIS; N BOND FORMATION; PHENAZINE-1-CARBOXYLIC ACID; ANTHRANILATE SYNTHASE; C-N; RIMINOPHENAZINE DERIVATIVES; POLYFLUOROAROMATIC AMINES;

D O I：

10.1016/j.bmc.2017.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenazines are natural products which are produced by bacteria or by archaeal Methanosarcina species. The tricyclic ring system enables redox processes, which producing organisms use for oxidation of NADH or for the generation of reactive oxygen species (ROS), giving them advantages over other microorganisms. In this review we summarize the progress in the field since 2005 regarding the isolation of new phenazine natural products, new insights in their biological function, and particularly the now almost completely understood biosynthesis. The review is complemented by a description of new synthetic methods and total syntheses of phenazines. (C) 2017 The Authors. Published by Elsevier Ltd.

引用

页码：6149 / 6166

页数：18

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