Hyperalgesia by synaptic long-term potentiation (LTP): an update

被引：125

作者：

Sandkuehler, Juergen ^{[1
]}

Gruber-Schoffnegger, Doris ^{[1
]}

机构：

[1] Med Univ Vienna, Ctr Brain Res, Dept Neurophysiol, A-1090 Vienna, Austria

来源：

CURRENT OPINION IN PHARMACOLOGY | 2012年 / 12卷 / 01期

基金：

奥地利科学基金会;

关键词：

SPINAL DORSAL-HORN; EVOKED FIELD POTENTIALS; LATE-PHASE LTP; CORD IN-VIVO; ANTERIOR CINGULATE CORTEX; AMPA RECEPTOR SUBUNITS; NECROSIS-FACTOR-ALPHA; METHYL-D-ASPARTATE; C-FIBER; INFLAMMATORY PAIN;

D O I：

10.1016/j.coph.2011.10.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Long-term potentiation of synaptic strength (LTP) in nociceptive pathways shares principle features with hyperalgesia including induction protocols, pharmacological profile, neuronal and glial cell types involved and means for prevention. LTP at synapses of nociceptive nerve fibres constitutes a contemporary cellular model for pain amplification following trauma, inflammation, nerve injury or withdrawal from opioids. It provides a novel target for pain therapy. This review summarizes recent progress which has been made in unravelling the properties and functions of LTP in the nociceptive system and in identifying means for its prevention and reversal.

引用

页码：18 / 27

页数：10

共 50 条

[1] LONG-TERM SYNAPTIC POTENTIATION
BROWN, TH
CHAPMAN, PF
KAIRISS, EW
KEENAN, CL
[J]. SCIENCE, 1988, 242 (4879) : 724 - 728
[2] Synaptic tagging and long-term potentiation
Uwe Frey
Richard G. M. Morris
[J]. Nature, 1997, 385 : 533 - 536
[3] Synaptic tagging and long-term potentiation
Frey, U
Morris, RGM
[J]. NATURE, 1997, 385 (6616) : 533 - 536
[4] LONG-TERM SYNAPTIC POTENTIATION IN THE AMYGDALA
CHAPMAN, PF
KAIRISS, EW
KEENAN, CL
BROWN, TH
[J]. SYNAPSE, 1990, 6 (03) : 271 - 278
[5] LONG-TERM POTENTIATION AS SYNAPTIC DIALOG
COLLEY, PA
ROUTTENBERG, A
[J]. BRAIN RESEARCH REVIEWS, 1993, 18 (01) : 115 - 122
[6] Long-term potentiation (LTP) at the primary olfactory synapse
Zimmer, LA
Ennis, M
Shipley, MT
[J]. CHEMICAL SENSES, 1995, 20 (06) : 345 - 345
[7] THE PROPERTIES OF THE LONG-TERM POTENTIATION (LTP) IN THE SUPERIOR COLLICULUS
OKADA, Y
[J]. PROGRESS IN BRAIN RESEARCH, 1993, 95 : 287 - 296
[8] Long-term potentiation (LTP) as a model of pavlovian conditioning
Kleschevnikov, AM
Voronin, LL
[J]. JOURNAL OF NEUROCHEMISTRY, 1998, 71 : S59 - S59
[9] QUANTAL MECHANISM OF LONG-TERM SYNAPTIC POTENTIATION
BAXTER, DA
BITTNER, GD
BROWN, TH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (17) : 5978 - 5982
[10] Long-term potentiation: Effects on synaptic coding
Ieong, R
Stiber, M
[J]. COMPUTATIONAL NEUROSCIENCE: TRENDS IN RESEARCH, 1997, 1997, : 87 - 92

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