Clinical Application of Three-Dimensionally Printed Biomaterial Polycaprolactone (PCL) in Augmentation Rhinoplasty

被引:27
|
作者
Park, Young Jin [1 ]
Cha, Jong Hyun [1 ]
Bang, Sa Ik [2 ]
Kim, So Young [3 ]
机构
[1] Kangnam Samsung Aesthet Plast Surg, 1306-1,HyoBong 601, Seoul 06614, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Plast Surg, Irwon Dong 50, Seoul 135, South Korea
[3] Inje Univ, Sch Med, Sanggye Paik Hosp, Dept Plast & Reconstruct Surg, 1342 Dongil Ro, Seoul 01757, South Korea
关键词
Rhinoplasty; Alloplastic implant; 3D PCL mesh; GRAFTS;
D O I
10.1007/s00266-018-1280-1
中图分类号
R61 [外科手术学];
学科分类号
摘要
BackgroundThis clinical study aimed to investigate the safety and surgical outcome of three-dimensionally (3D) fabricated polycaprolactone (PCL) mesh in rhinoplasty. In particular, this study explored how a 3D-printed PCL mesh performs as a bioabsorbable scaffold after a long period following implantation. MethodsA retrospective review of 101 patients who received primary or secondary rhinoplasty with a PCL mesh was performed. Patient demographics and surgery-related outcomes were examined. Clinical efficacy and safety were evaluated using the Global Aesthetic Improvement Scale at postoperative 18months. From two revisional cases, a biopsy specimen of implanted PCL was acquired and histopathological analysis was performed. ResultsOf all the patients, 98.0% showed no postoperative infection-related foreign body reaction or distinct abnormal reaction, and the implants were observed to maintain long-term efficacy until 18-month follow-up. In patients who received spreader grafts, significant differences between preoperative and postoperative Cottle sign scores were found. Histopathological analysis showed features of adjacent tissue infiltration into pores of the PCL mesh and regeneration of neo-cartilaginous tissue and collagen around the mesh 20months after implantation. ConclusionThis study demonstrates that a novel biodegradable PCL mesh with a 3D structure is a safe and effective material for corrective rhinoplasty because it is easy to use and capable of maintaining its volume in the long term without foreign body response. This biocompatible material will have a wide range of applications as the most suitable alternative to nonabsorbable materials in rhinoplasty and reconstruction surgeries, such as fashioning spreader grafts and septal extension grafts.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
引用
收藏
页码:437 / 446
页数:10
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