Discovery of novel inhibitors of 11β-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling

被引：40
|
作者：
Yang, Huaiyu [2 ,3 ]
Dou, Wei [1 ]
Lou, Jing [1 ]
Leng, Ying [1 ]
Shen, Jianhua [2 ,3 ,4 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Beijing 100864, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China
[4] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 04期
基金：
中国国家自然科学基金;
关键词：
11; beta-HSD1; beta-HSD2; inhibitor; docking; pharmacophore;
D O I：
10.1016/j.bmcl.2008.01.020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) is a potential target for treatment of diabetes and metabolic syndrome. Docking and pharmacophore modeling have been used to discover novel inhibitors of 11 beta-HSD1. Several compounds, with large structural diversity and good potency against 11 beta-HSD1, have been found and their potency was determined by the enzyme assay. New scaffolds of 11 beta-HSD1 inhibitors are also reported. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1340 / 1345
页数：6
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