Involvement of histone deacetylases (HDAC) in the molecular regulatory pathway of Cholesterol 7α-hydroxylase: an in vitro approach with selective HDAC inhibitors

被引:0
|
作者
Fiorino, E.
Gilardi, F. [1 ,2 ]
Multineddu, C. [1 ]
Mitro, N. [1 ]
Giudici, M. [1 ]
Godio, C.
Galmozzi, A. [1 ]
De Fabiani, E. [1 ]
Caruso, D. [1 ]
Crestani, M. [1 ]
机构
[1] Univ Milan, Lab G Galli, Dpt Sci Farmacol, I-20122 Milan, Italy
[2] Univ Lausanne, Ctr Investigat Genom, CH-1015 Lausanne, Switzerland
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中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
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页码:179 / 179
页数:1
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  • [1] Generation of a liver-specific HDAC7 KO mouse model and effect of selective HDAC inhibitors on cholesterol 7α-hydroxylase gene in mice
    Multineddu, C.
    Gilardi, F.
    Fiorino, E.
    Giudici, M.
    Galmozzi, A.
    Mitro, N.
    De Fabiani, E.
    Caruso, D.
    Crestani, M.
    [J]. FEBS JOURNAL, 2011, 278 : 184 - 184
  • [2] Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and In Vitro Alcohol Treatment and Their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat
    Agudelo, Marisela
    Figueroa, Gloria
    Parira, Tiyash
    Yndart, Adriana
    Munoz, Karla
    Atluri, Venkata
    Samikkannu, Thangavel
    Nair, Madhavan P.
    [J]. PLOS ONE, 2016, 11 (06):
  • [3] Novel and selective inhibitors of histone deacetylases (HDAC) 1 and 2 synergize with DNA methyltransferase inhibitor azacitidine in acute myeloid leukemia (AML)
    Min, Chengyin
    Quayle, Steven N.
    Huang, Pengyu
    Shearstone, Jeffrey R.
    Jones, Simon S.
    Yang, Min
    [J]. CANCER RESEARCH, 2016, 76
  • [4] Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases
    Beckers, Thomas
    Mahboobi, Siavosh
    Sellmer, Andreas
    Winkler, Matthias
    Eichhorn, Emerich
    Pongratz, Herwig
    Maier, Thomas
    Ciossek, Thomas
    Baer, Thomas
    Kelter, Gerhard
    Fiebig, Heinz-Herbert
    Schmidt, Mathias
    [J]. MEDCHEMCOMM, 2012, 3 (07) : 829 - 835
  • [5] Novel and selective inhibitors of histone deacetylases (HDAC) 1 and 2 significantly enhance the activity of the DNA methyltransferase inhibitor azacitidine in acute myeloid leukemia (AML)
    Min, Chengyin
    Quayle, Steven N.
    Tamang, David
    Jones, Simon S.
    Yang, Min
    [J]. CANCER RESEARCH, 2015, 75
  • [6] Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy
    Ontoria, Jesus M.
    Altamura, Sergio
    Di Marco, Annalise
    Ferrigno, Federica
    Laufer, Ralph
    Muraglia, Ester
    Palumbi, Maria Cecilia
    Rowley, Michael
    Scarpelli, Rita
    Schultz-Fademrecht, Carsten
    Scrafini, Sergio
    Steinkuehler, Christian
    Jones, Philip
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (21) : 6782 - 6789
  • [7] Identification of Molecular Interactions within Histone Deacetylase Isozymes for the Development of Selective HDAC2 Inhibitors for the Design of Targeted Cancer Therapies
    May, Xavier
    Watkins, Davita
    Stoddard, Shana V.
    [J]. FASEB JOURNAL, 2017, 31
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    Anand, Asha
    Ghosh, Powsali
    Singh, Ravi
    Bajad, Nilesh Gajanan
    Kumar, Ashok
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    [J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023,
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    Dukic-Stefanovic, Sladjana
    Ludwig, Friedrich-Alexander
    Guendel, Daniel
    Teodoro, Rodrigo
    Kopka, Klaus
    Brust, Peter
    Hansen, Finn
    Scheunemann, Matthias
    [J]. NUCLEAR MEDICINE AND BIOLOGY, 2022, 108 : S215 - S216
  • [10] Exploration of anticancer potential of hydroxamate derivatives as selective HDAC8 inhibitors using integrated structure and ligand based molecular modeling approach
    Shirbhate, Ekta
    Divya
    Patel, Preeti
    Patel, Vijay K.
    Veerasamy, Ravichandran
    Rajak, Harish
    [J]. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2021, 60 (01): : 136 - 147