Antibody response to purified chick embryo cell vaccine in equines for production of equine rabies immune globulin

被引：3
|
作者：
Goel, SK [1 ]
Sharma, S [1 ]
Singh, US [1 ]
机构：
[1] Cent Res Inst, Kasauli 173204, India
来源：
BIOLOGICALS | 2003年 / 31卷 / 04期
关键词：
PCECV (Rabipur); ERIG; PET;
D O I：
10.1016/S1045-1056(03)00059-9
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Rabies is endemic in India. The post exposure treatment of class three bite cases, as recommended by the World Health Organization, must involve the use of rabies immunoglobulin as soon as possible and up to the seventh day of start of anti rabies vaccination. The annual requirement in India as projected by the Ministry of Health, Government of India is about 1500 liters of purified anti rabies serum (ERIG). Central Research Institute (CRI), Kasauli, being the sole producer of ERIG in India, an effort was made to increase the production of ERIG by the use of tissue culture vaccine (Human) for primary immunization of equines. It also involved changing the vaccine from horse brain suspension to tissue culture vaccine by eliminating horse sacrifice for antigen preparation. A better immune response was obtained. (C) 2003 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：233 / 236
页数：4
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