Electrochemical strategies for N-cyanation of secondary amines and α C-cyanation of tertiary amines under transition metal-free conditions

被引：12

作者：

Fu, Zhengjiang ^{[1
,2
]}

Fu, Yaping ^{[1
]}

Yin, Jian ^{[1
]}

Hao, Guangguo ^{[1
]}

Yi, Xuezheng ^{[1
]}

Zhong, Tingting ^{[1
]}

Guo, Shengmei ^{[1
]}

Cai, Hu ^{[1
]}

机构：

[1] Nanchang Univ, Coll Chem, Nanchang 330031, Jiangxi, Peoples R China

[2] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210023, Peoples R China

来源：

GREEN CHEMISTRY | 2021年 / 23卷 / 23期

基金：

中国国家自然科学基金;

关键词：

MEDIATED DECARBOXYLATIVE CYANATION; ARYL CARBOXYLIC-ACIDS; ANODIC CYANATION; CATALYST; NITRILES; NITROGEN;

D O I：

10.1039/d1gc02529e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Transition metal-free electrochemical approaches for the N-cyanation of secondary amines and the alpha C-cyanation of tertiary amines have been well established, with products being obtained in moderate to good yields and with good functional group tolerance under ambient conditions. The synthetic application of the protocols has been highlighted through scale-up experiments in a galvanostatic mode. Preliminary mechanistic investigation has confirmed that TBAB played a critical role in N-cyanation transformation and has indicated that the transformation might proceed via a free radical process.

引用

页码：9422 / 9427

页数：6

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