Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice

被引：2

作者：

Armstrong, JF

Hooper, ML

机构：

[1] Univ Edinburgh, Western Gen Hosp, Sir Alastair Currie CRC Labs, Mol Med Ctr, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Dept Pathol, Edinburgh EH8 9AG, Midlothian, Scotland

来源：

BRITISH JOURNAL OF CANCER | 1998年 / 78卷 / 04期

基金：

英国医学研究理事会;

关键词：

Rb-1; retinoblastoma; pituitary tumour; imprinting;

D O I：

10.1038/bjc.1998.519

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The previously reported earlier onset of pituitary tumours in cross-bred mice inheriting a mutant Rb-1 allele paternally has been ascribed to imprinting of an Rb-1-linked gene. Here, we demonstrate that, as predicted from this mechanism, there is no effect of the parent of origin of the mutation in inbred mice.

引用

页码：484 / 485

页数：2

共 3 条

[1] Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice
JF Armstrong
ML Hooper
British Journal of Cancer, 1998, 78 : 484 - 485
[2] HETEROZYGOUS RB-1(DELTA-20)/+ MICE ARE PREDISPOSED TO TUMORS OF THE PITUITARY-GLAND WITH A NEARLY COMPLETE PENETRANCE
HU, NP
GUTSMANN, A
HERBERT, DC
BRADLEY, A
LEE, WH
LEE, EYHP
ONCOGENE, 1994, 9 (04) : 1021 - 1027
[3] PARENTAL ORIGIN OF MUTANT ALLELE DOES NOT EXPLAIN ABSENCE OF GENE DOSE IN X-LINKED HYP MICE
QIU, ZQ
TENENHOUSE, HS
SCRIVER, CR
GENETICAL RESEARCH, 1993, 62 (01) : 39 - 43

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