9,10-Dibromo-N-aryl-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-diones: Synthesis and Investigation of Their Effects on Carbonic Anhydrase Isozymes I, II, IX, and XII

被引：32

作者：

Goksu, Haydar ^{[1
,2
]}

Topal, Meryem ^{[3
]}

Keskin, Ali ^{[2
]}

Gultekin, Mehmet S. ^{[2
]}

Celik, Murat ^{[2
]}

Gulcin, Ilhami ^{[2
,4
]}

Tanc, Muhammet ^{[5
]}

Supuran, Claudiu T. ^{[5
]}

机构：

[1] Duzce Univ, Kaynasli Vocat Coll, Duzce, Turkey

[2] Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey

[3] Gumushane Univ, Vocat Sch Hlth Serv, Dept Med Serv & Tech, Gumushane, Turkey

[4] King Saud Univ, Dept Zool, Coll Sci, Riyadh, Saudi Arabia

[5] Univ Florence, Dipartimento NEUROFARBA, Sez Sci Farmaceut, Florence, Italy

来源：

ARCHIV DER PHARMAZIE | 2016年 / 349卷 / 06期

关键词：

Carbonic anhydrase; Enzyme inhibition; Enzyme purification; Isoenzyme; TROUT ONCORHYNCHUS-MYKISS; ACETYLCHOLINE ESTERASE INHIBITORS; ISOENZYMES HCA I; THERAPEUTIC APPLICATIONS; ENZYME-ACTIVITY; MYCOBACTERIUM-TUBERCULOSIS; SULFONAMIDE DERIVATIVES; SELECTIVE INHIBITORS; TUMOR-GROWTH; VIVO;

D O I：

10.1002/ardp.201600047

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-substituted maleimides were synthesized from maleic anhydride and primary amines. 1,4-Dibromodibenzo[e,h]bicyclo-[2,2,2]octane-2,3-dicarboximide derivatives (4a-f) were prepared by the [4+2] cycloaddition reaction of dibromoanthracenes with the N-substituted maleimide derivatives. The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory effects of the new derivatives were assayed against the human (h) isozymes hCA I, II, IX, and XII. All tested bicyclo dicarboximide derivatives exhibited excellent inhibitory effects in the nanomolar range, with K-i values in the range of 117.73-232.87 nM against hCA I and of 69.74-111.51 nM against hCA II, whereas they were low micromolar inhibitors against hCA IX and XII.

引用

页码：466 / 474

页数：9

共 3 条

[1] Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII
Brzozowski, Zdzislaw
Slawinski, Jaroslaw
Innocenti, Alessio
Supuran, Claudiu T.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (09) : 3656 - 3661
[2] Carbonic anhydrase inhibitors. Regioselective synthesis of novel series 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII
Brzozowski, Zdzislaw
Slawinski, Jaroslaw
Vullo, Daniela
Supuran, Claudiu T.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 56 : 282 - 291
[3] New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII
Meleddu, Rita
Maccioni, Elias
Distinto, Simona
Bianco, Giulia
Melis, Claudia
Alcaro, Stefano
Cottiglia, Filippo
Ceruso, Mariangela
Supuran, Claudiu T.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (16) : 3281 - 3284

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