Study on the molecular recognition interaction of β-cyclodextrin with aminobenzoic acid isomer

被引:0
|
作者
Yang, Y [1 ]
Shuang, SM [1 ]
Chao, JB [1 ]
Zhang, GM [1 ]
Ding, HY [1 ]
Dong, C [1 ]
机构
[1] Shanxi Univ, Inst Adv Chem, Coll Chem & Chem Engn, Taiyuan 030006, Peoples R China
关键词
aminobenzoic acid; molecular recognition; fluorescence spectrum method; NMR;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The molecular recognition interaction of beta-CD with ortho-, meta-, para-aminobenzoic acid isomers was systematically investigated by using steady-state fluorescence spectrum method. The effect of pH value of medium on the inclusion process was discussed in detail. The formation constants of inclusion complexes were determined and the inclusion ability of beta-CD to aminobenzoic acid isomers was compared. The related mechanism was proposed. Meanwhile, the inclusion position was studied based on 1D, 2D NMR technique. The relative stereodiagrams of inclusion complexes were proposed by combining molecular dynamics calculation and computer simulation technique. The results obtained from molecular dynamics calculation were in accordance with the results of NMR.
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页码:176 / 182
页数:7
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