Magnetic biomineralisation in Huntington's disease transgenic mice

被引：6
|
作者：
Beyhum, W [1 ]
Hautot, D [1 ]
Dobson, J [1 ]
Pankhurst, QA [1 ]
机构：
[1] UCL, London Ctr Nanotechnol, London WC1E 7HN, England
来源：
FIFTH INTERNATIONAL CONFERENCE ON FINE PARTICLE MAGNETISM | 2005年 / 17卷
关键词：
D O I：
10.1088/1742-6596/17/1/008
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The concentration levels of biogenic magnetite nanoparticles in transgenic R6/2 Huntington's disease (HD) mice have been investigated, using seven control and seven HD mice each from an 8 week-old litter and from a 12 week-old litter. Hysteresis and isothermal remnant magnetisation data were collected on a SQUID magnetometer, and analysed using a model comprising dia/paramagnetic, ferrimagnetic and superparamagnetic contributions, to extract the magnetite and ferritin concentrations present. It was found that magnetite was present in both superparamagnetic and blocked states. A larger spread and higher concentration of magnetite levels was found in the diseased mice for both the 8 week-old and 12 week-old batches, compared to the controls.
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收藏
页码：50 / 53
页数：4
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