Synthesis of N-substituted aryl amidines by strong base activation of amines

被引：15

作者：

Khalifa, Muhammad M. ^{[1
]}

Bodner, Micah J. ^{[1
]}

Berglund, J. Andrew ^{[1
,2
]}

Haley, Michael M. ^{[1
]}

机构：

[1] Univ Oregon, Dept Chem & Biochem, Eugene, OR 97403 USA

[2] Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 27期

基金：

美国国家卫生研究院;

关键词：

Amidine; Amine; Nitrile; Base-activation; Strong base; ANTIPROTOZOAL ACTIVITY; MYOTONIC-DYSTROPHY; DERIVATIVES; PENTAMIDINE; BINDING; NITRILES; ANALOGS; AGENTS; INHIBITOR; MOLECULES;

D O I：

10.1016/j.tetlet.2015.05.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe an efficient method for the direct preparation of N-substituted aryl amidines from nitriles and primary amines. The protocol employs activation of amines by a strong base and provides greater access to a pharmaceutically relevant functional group. This synthetic approach tolerates deactivated nitriles, nitriles with competing substitution sites, and aryl amines. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4109 / 4111

页数：3

共 50 条

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[J]. TETRAHEDRON, 1981, 37 (16) : 2909 - 2910
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