Ionic Dioxidovanadium(V) Complexes with Schiff-Base Ligands as Potential Insulin-Mimetic Agents-Substituent Effect on Structure and Stability

被引：3
|
作者：
Jurowska, Anna [1 ]
Szklarzewicz, Janusz [1 ]
Hodorowicz, Maciej [1 ]
Serafin, Wiktoria [1 ]
Zangrando, Ennio [2 ]
Mahmoudi, Ghodrat [3 ]
机构：
[1] Jagiellonian Univ, Fac Chem, Gronostajowa 2, PL-30387 Krakow, Poland
[2] Univ Trieste, Dept Chem & Pharmaceut Sci, Via L Giorgieri 1, I-34127 Trieste, Italy
[3] Univ Maragheh, Fac Sci, Dept Chem, POB 55181-83111, Maragheh, Iran
来源：
MOLECULES | 2022年 / 27卷 / 20期
关键词：
vanadium; ionic complexes; Schiff base ligand; crystal structure; UV-Vis spectra; VANADIUM COMPOUNDS; DIOXIDO-VANADIUM(V) COMPLEXES; CRYSTAL-STRUCTURE; COPPER(II); CHEMISTRY; BMOV;
D O I：
10.3390/molecules27206942
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Four dioxidovanadium(V) complexes with Schiff-base ligands based on 2-hydroxybenzhydrazide with four different substituted salicylaldehydes (5-chlorosalicylaldehyde, 3,5-dichlorosalicylaldehyde, 5-nitrosalicylaldehyde, 3-bromo-5-chlorosalicylaldehyde) were synthesized and described, by using V2O5 and triethylamine. The single crystal X-ray structure measurements as well as elemental analyses and IR spectra confirmed the formulas of the ionic complexes with a protonated triethylamine acting as counterion, HTEA[VO2(L)] (HL = Schiff-base ligand). The kinetic stability of the complexes at pH = 2 and 7 was discussed with respect to the neutral vanadium(V) complexes previously studied as potential insulin-mimetic agents. A correlation between the substituents in an aromatic ring of the Schiff-base ligands with crystal packing, and also with the stability of the compounds, was presented.
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页数：12
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