Variable protection after vaccination of broiler chickens against necrotic enteritis using supernatants of different Clostridium perfringens strains

被引：30
|
作者：
Lanckriet, A. [1 ]
Timbermont, L. [1 ]
Eeckhaut, V. [1 ]
Haesebrouck, F. [1 ]
Ducatelle, R. [1 ]
Van Immerseel, F. [1 ]
机构：
[1] Univ Ghent, Fac Vet Med, Dept Pathol Bacteriol & Avian Dis, Res Grp Vet Publ Hlth & Zoonoses, B-9820 Merelbeke, Belgium
来源：
VACCINE | 2010年 / 28卷 / 36期
关键词：
Clostridium perfringens; Vaccine; Necrotic enteritis; VIRULENCE; TOXIN; IMMUNIZATION; PREVALENCE; DISEASE; NETB;
D O I：
10.1016/j.vaccine.2010.06.035
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Necrotic enteritis is an economically important disease of chickens caused by Clostridium perfringens. Immunity to necrotic enteritis is not fully characterized yet, but previous reports indicate that immunoprotective potential is present in the secreted component of C perfringens. This study aimed to compare the vaccine potential of the supernatants of eight chicken strains of C. perfringens differing in origin, level of alpha toxin production and presence of netB gene. The supernatant of only one strain provided full protection, while one other strain provided partial protection against a severe infection challenge. Our results indicate that the protective characteristics of the supernatants are not solely based on the presence of NetB or alpha toxin. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5920 / 5923
页数：4
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