Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients

被引：0

作者：

Sakuyama, Kenichi ^{[1
]}

Meguro, Akira

Ota, Masao ^{[2
]}

Ishihara, Mami

Uemoto, Riyo

Ito, Haruyasu

Okada, Eiichi ^{[3
]}

Namba, Kenichi ^{[4
]}

Kitaichi, Nobuyoshi ^{[5
]}

Morimoto, Shin-ichiro ^{[6
]}

Kaburaki, Toshikatsu ^{[7
]}

Ando, Yasutaka ^{[8
,9
]}

Takenaka, Shinobu ^{[10
]}

Yuasa, Takenosuke ^{[11
]}

Ohno, Shigeaki ^{[12
]}

Inoko, Hidetoshi ^{[13
]}

Mizuki, Nobuhisa

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Ophthalmol & Visual Sci, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[2] Shinshu Univ, Sch Med, Dept Lab Med, Matsumoto, Nagano 390, Japan

[3] Okada Eye Clin, Yokohama, Kanagawa, Japan

[4] Hokkaido Univ, Grad Sch Med, Dept Ophthalmol, Sapporo, Hokkaido, Japan

[5] Hlth Sci Univ Hokkaido, Dept Ophthalmol, Sapporo, Hokkaido, Japan

[6] Fujita Hlth Univ, Sch Med, Dept Internal Med, Div Cardiol, Toyoake, Aichi 47011, Japan

[7] Univ Tokyo, Sch Med, Dept Ophthalmol, Bunkyo Ku, Tokyo 113, Japan

[8] Kitasato Inst Hosp, Dept Ophthalmol, Minato Ku, Tokyo, Japan

[9] Keio Univ, Sch Med, Dept Ophthalmol, Shinjuku Ku, Tokyo, Japan

[10] Kumamoto City Hosp, Dept Resp Dis, Kumamoto, Japan

[11] Yuasa Eye Clin, Osaka, Japan

[12] Hokkaido Univ, Grad Sch Med, Dept Ocular Inflammat & Immunol, Sapporo, Hokkaido, Japan

[13] Tokai Univ, Sch Med, Div Mol Med Sci & Mol Med, Dept Mol Life Sci, Isehara, Kanagawa 25911, Japan

来源：

MOLECULAR VISION | 2012年 / 18卷 / 56期

关键词：

ALVEOLAR MACROPHAGES; GENE POLYMORPHISMS; LYMPH-NODES; PROPIONIBACTERIAL DNA; PULMONARY SARCOIDOSIS; SYSTEMIC-SCLEROSIS; MEDICAL PROGRESS; DISEASE-ACTIVITY; INTERLEUKIN-10; MYCOBACTERIAL;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpose: To investigate whether interleukin 10 (IL10) gene polymorphisms are associated with the development of sarcoidosis in Japanese patients. Methods: Two hundred and eighty-eight Japanese sarcoidosis patients and 310 Japanese healthy controls were recruited. We genotyped 9 single-nucleotide polymorphisms in IL10 and assessed the allelic diversity between cases and controls. Results: No significant differences in the frequency of IL10 alleles, genotypes, and haplotypes in the sarcoidosis cases compared to the controls were detected. Conclusions: Our results suggest that IL10 polymorphisms are not significantly related to the pathogenesis of sarcoidosis in the Japanese population.

引用

页码：512 / 518

页数：7

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