Systematic review of pharmacogenomics and adverse drug reactions in paediatric oncology patients

被引：10
|
作者：
Conyers, Rachel [1 ,3 ]
Devaraja, Subalatha [2 ,3 ]
Elliott, David [1 ]
机构：
[1] Murdoch Childrens Res Inst, Melbourne, Vic, Australia
[2] Univ Melbourne, Dept Med, Melbourne, Vic, Australia
[3] Royal Childrens Hosp, Childrens Canc Ctr, Level 2,Flemington Rd, Melbourne, Vic 3052, Australia
来源：
PEDIATRIC BLOOD & CANCER | 2018年 / 65卷 / 04期
关键词：
adverse drug reactions; genome wide association studies; paediatric oncology; pharmacogenomics; single-nucleotide polymorphisms; ACUTE LYMPHOBLASTIC-LEUKEMIA; HIGH-DOSE METHOTREXATE; ANTHRACYCLINE-INDUCED CARDIOTOXICITY; REDUCTASE GENE POLYMORPHISMS; METHYLENETETRAHYDROFOLATE REDUCTASE; PERIPHERAL NEUROPATHY; CHILDHOOD-CANCER; TOXIC ENCEPHALOPATHY; CANDIDATE GENES; FOLATE PATHWAY;
D O I：
10.1002/pbc.26937
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Many paediatric patients with cancer experience significant chemotherapy side effects. Predisposition to drug reactions is governed by single nucleotide polymorphisms (SNPs). We performed a systematic review of the literature from 2006 through 2016. Outcomes of interest included patient characteristics, cancer type drug of interest, genes investigated, toxicity identified and genetic polymorphisms implicated. The primary toxicities studied were neurotoxicity cardiotoxicity, osteonecrosis, and thromboembolism and hypersensitivity reactions. The retrieved studies were grouped according to toxicity reported and SNP associations. This review highlights the discoveries to date in pharmacogenomics and paediatric oncology along with highlighting some of the important limitations in the area.
引用
收藏
页数：12
相关论文
共 50 条
  • [1] PHARMACOGENOMICS OF SERIOUS ADVERSE DRUG REACTIONS IN PEDIATRIC ONCOLOGY
    Ross, Colin J. D.
    Visscher, Henk
    Rassekh, S. Rod
    Castro-Pastrana, Lucila I.
    Shereck, Evan
    Carleton, Bruce
    Hayden, Michael R.
    [J]. JOURNAL OF POPULATION THERAPEUTICS AND CLINICAL PHARMACOLOGY, 2011, 18 (01): : E134 - E151
  • [2] Potential role of pharmacogenomics in reducing adverse drug reactions - A systematic review
    Phillips, KA
    Veenstra, DL
    Oren, E
    Lee, JK
    Sadee, W
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (18): : 2270 - 2279
  • [3] Pharmacogenomics of adverse drug reactions
    Daly, Ann K.
    [J]. GENOME MEDICINE, 2013, 5
  • [4] Pharmacogenomics of adverse drug reactions
    Ann K Daly
    [J]. Genome Medicine, 5
  • [5] Pharmacogenomics and adverse drug reactions
    Chiba, K
    [J]. JAPANESE JOURNAL OF PHARMACOLOGY, 2002, 88 : 46P - 46P
  • [6] Pharmacogenomics and adverse drug reactions
    Amur, Shashi
    Zineh, Issam
    Abernethy, Darrell R.
    Huang, Shiew-Mei
    Lesko, Lawrence J.
    [J]. PERSONALIZED MEDICINE, 2010, 7 (06) : 633 - 642
  • [7] Systematic review of paediatric studies of adverse drug reactions from pharmacovigilance databases
    Cliff-Eribo, Kennedy Obebi
    Sammons, Helen
    Choonara, Imti
    [J]. EXPERT OPINION ON DRUG SAFETY, 2016, 15 (10) : 1321 - 1328
  • [8] Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions
    Tong, Hang
    Phan, Nga V. T.
    Nguyen, Thanh T.
    Nguyen, Dinh, V
    Vo, Nam S.
    Le, Ly
    [J]. PHARMACOGENOMICS & PERSONALIZED MEDICINE, 2021, 14 : 61 - 75
  • [9] Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy
    Elzagallaai, Abdelbaset A.
    Carleton, Bruce C.
    Rieder, Michael J.
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021, 2021, 61 : 679 - 699
  • [10] The role of pharmacogenomics in adverse drug reactions
    Cacabelos, Ramon
    Cacabelos, Natalia
    Carril, Juan C.
    [J]. EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2019, 12 (05) : 407 - 442
12345