Unique three-way translocation, t(3;14;18)(q27;q32;q21), in follicular lymphoma

被引：5
|
作者：
Okano, A [1 ]
Nakano, S [1 ]
Namura, K [1 ]
Yamada, N [1 ]
Uchida, R [1 ]
Fuchida, S [1 ]
Okamoto, M [1 ]
Ochiai, N [1 ]
Shimazaki, C [1 ]
机构：
[1] Kyoto Prefectural Univ Med, Dept Med, Div Hematol & Oncol, Kamigyo Ku, Kyoto 6028566, Japan
来源：
CANCER GENETICS AND CYTOGENETICS | 2005年 / 159卷 / 02期
关键词：
D O I：
10.1016/j.cancergencyto.2004.10.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A 43-year-old woman was diagnosed as having stage IV follicular lymphoma. Phenotypically, the lymphoma cells were CD5(-), CD10(+), CD19(+), CD20(+), CD23(-), HLA-DR(+), and IgM-lambda(+). Conventional chromosomal analysis showed a three-way t(3;14;18)(q27;q32;q21) in the lymphoma cells, which was confirmed by spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH). Immunohistochemistry revealed that both BCL2 and BCL6 proteins were expressed in the lymphoma cells, whereas only the BCL6 gene, and not the BCL2 gene, was rearranged by Southern blotting. The patient received combination chemotherapy and has been well for 3 years. This is the first reported case showing a three-way translocation involving 2 major lymphoma-specific abnormalities, 3q27 and t(14,18)(q32;q21). (c) 2005 Elsevier Inc. All rights reserved.
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收藏
页码：174 / 176
页数：3
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