The Osteoporosis Assessment Questionnaire (OPAQ): A reliable and valid disease-targeted measure of health-related quality of life (HRQOL) in osteoporosis

The Osteoporosis Assessment Questionnaire (OPAQ) is a reliable and valid disease-targeted self assessment questionnaire of health-related quality of life (HRQOL) in osteoporosis first developed in 1993. OPAQ has been used in two international multicenter trials. OPAQ structure includes 14-18 domains which may be grouped into four dimensions: physical function, emotional status, symptoms and social interaction. OPAQ exists in two long versions: OPAQ 1.0 (73 questions) and OPAQ 2.0 (60 questions) OPAQ also exists as a short version: OPAQ-SV (34 questions) with three dimensions: physical function, emotional status and back pain. OPAQ detects changes in HRQOL with prevalent vertebral and nonvertebral fracture. Decreases in HRQOL are seen with increasing numbers of prevalent vertebral fractures. OPAQ is sensitive to changes in HRQOL of incident vertebral fracture.